I think the JT is more or less fine, maybe a slight (180) hp reduction but also a slight cost reduction? I'd like to see less of a drastic power level between the super heavies and the other tanks (mainly mediums).
As for the ISU, I think it needs some combination of an hp decrease (180-240), removal of the mounted MG, reduction to 60 range, a major AoE profile redesign and/or drastically less penetration.
It absolutely needs focused sight removed and concrete round should probably replace it's vet 1 ability, or be removed entirely. It's so un-necessary.
Right now the ISU is simply too good at killing tanks (it is so strong vs Panthers/Tigers and even gives the Elefant some trouble) as well as 1 shotting squads. I'd start with a drastic AoE profile change to where the radius of 1-shotting infantry models is much smaller. It would probably still kill 1-2 models per shot, and have a chance to wipe non-full Hp squads but by the time the ISU hits you really should have healing.
A range reduction would let AT guns sort of "wall" for you, any time the ISU shoots at least the AT guns could shoot back. Right now the only (semi) counter to the ISU is the JT/Elefant, and those can really only play keep-away because of the ISU's massive HP pool and the insane (but necessary) reload on the JT/Ele.
Removal of the 0.50 cal mounted MG would let schreck flanks actually do things to the ISU, right now the mounted MG just shreds infantry while they try to get into schreck range.
Penetration nerf would let Tigers/Panther front armor absorb shots to better spot for other AT, but with other nerfs this probably wouldn't be necessary. I'd much rather see the ISU performance vs infantry be drastically toned down but keep it's AT capabilities.
Oh and one sweeping change I'd make - heavies no longer crew shock other tanks. It's a really stupid RNG mechanic that can swing games for no reason at all. Target weak point should probably be redesigned as well.
I disagree about some parts you wrote about the ISU. Lowering its damage versus tanks is going to hurt the SOviet AT a lot. SOviets already lack AT to deal with heavier German tanks. ISU's AT abilities is really the last hope to fight heavies such as KT and Jagdtiger. It is a very delicate issue so I am just pointing out that SOviets lack hard AT. Nerfing ISU is going to destroy the 4v4 game mode even further.
I like your Jagdtiger changes. I think they are alright. Personally, I would like to see its ability to shoot through objects removed. It would prevent players form just camping behind a building and shooting through it without any counterplay.
Personally, I would cut the ISU range down to 60 and buff its AT. The ISU would still be powerful but would have to enter into harms way to do damage. I would also remove the focus sight ability.
ISU and Jagdtiger are very difficult to balance. I would love Relic to keep these units as authentic as possible; The ISU is a very powerful assault gun and the Jagdtiger is a well-armed and heavily armored tank destroyer. These units should be powerful but come with weaknesses.