2 flanking tanks can take care of it, and you never have to worry about Button when up against it (unless in a team game, but that's cheese game mode for you) so you can afford to be aggressive; even if you lose 2 P4s destroying it, you still come out on top resource wise.
To be true, there's a commander with ISU & guards.
ISU-152 is astonishingly good, but is much more vulnerable than all others heavy tanks. Its slow, doesn't have turret and its armor is not good.
You don't even need Tigers to destroy it, even a good flanking puma can destroy it.
I think that ISU-152 OPness depends more of the map that you're playing than the unit itself. But well, that happens with Elefant too and elefant is much harder to be countered. (Yes, i know that elefant only damages tanks, but seriously you need something besides grens+lmg to rape soviet infantry?)