The lower you are on the ladder, the more probable it is to be matched with a higher skilled opponent. At the same time, this loss will result in a lower ELO adjustment.
It actually depends. Without taking into a considiration super low ranks, if you have multiple opponents simular to your rank, but among them there is a player with a significantly highter rank then yours, you still will lose significant amount of ELO. The same way you will lose significant amount of ELO if you are paired against lower ranks, having simular low ranks teammates.
But it actually would be really insteresting, if some one made a research of how actually ELO is calculated in a match with multiple people being much higter\lower rank then the others.
I even think that, there might be even some sort of way system tries to balance the match via matching differently ranked players. Because its a common situation where, for instance, top 100 player could be matched with multiple rank 700-1000 players, against full house of ranks 300-400 players.