I mean they could be used more like PaK 43 but they would be weaker of course. They could switch stance between arty mode and AT mode like KV-2.
ML-20 is the same gun as ISU-152 have and leFH was also able to engage tanks:
An AT role was certainly envisioned for the le FH 18. Figures from a reprint of Datenblätter für Heeres-Waffen, -Fahrzeuge, -Gerät give a penetration at an impact angle of 60 deg from the horizontal of 56/44,5 mm (at 100/1500m) with charge 5 and 64/49 mm with charge 6 for the 10 cm PzGr AP shell; adequate performance against most early war tanks. Better penetration was obtained with HEAT shells, e.g. 100 mm at all distances with 10 cm Gr 39 rot HL/C.
There was also an APDS shell, 10,5 cm Pzgr. 39 (TS) with a penetration of 90 mm at 500 m but according to Waffen und Geheimwaffen des Deutschen Heeres 1933-1945 by Fritz Hahn it remained experimental.
Markus
During the French campaign the leFH 18 was often pressed into service in the anti-tank role when isolated pockets of heavily armoured French tanks, like the Char B and Somua, made breakthroughs. The 10.cm leFH 18 and the famed "88" were often the only weapons available to stop these thunderous beasts.