1v1 players would disagree.
In any case, if the game has any e-sport aspirations, it would need to set its mind on a mode to be the "core" experience. SC, WC3, SC2 were all 1v1 focused.
Balancing things based on 2v2 would probably be the worst imo. You still can't balance it enough for the larger team games, while detracting from the core competitive focus that 1v1 is and should be.
+1 E-sports and competitions are more commonly 1v1.